The Miyoshi Lab

Publications

2024

Pathophysiology of human hearing loss associated with variants in myosins
Pathophysiology of human hearing loss associated with variants in myosins
Takushi Miyoshi, Inna A. Belyantseva, Mrudhula Sajeevadathan, Thomas B. Friedman
Frontiers in Physiology  ·  18 Mar 2024  ·  doi:10.3389/fphys.2024.1374901

2022

Late-onset hearing loss case associated with a heterozygous truncating variant of <scp><i>DIAPH1</i></scp>
Late-onset hearing loss case associated with a heterozygous truncating variant of DIAPH1
Bong Jik Kim, Takushi Miyoshi, Taimur Chaudhry, Thomas B. Friedman, Byung Yoon Choi, Takehiko Ueyama
Clinical Genetics  ·  02 Feb 2022  ·  doi:10.1111/cge.14115

2021

Fast-dissociating but highly specific antibodies are novel tools in biology, especially useful for multiplex super-resolution microscopy
Fast-dissociating but highly specific antibodies are novel tools in biology, especially useful for multiplex super-resolution microscopy
Takushi Miyoshi, Thomas B. Friedman, Naoki Watanabe
STAR Protocols  ·  01 Dec 2021  ·  doi:10.1016/j.xpro.2021.100967
Human deafness-associated variants alter the dynamics of key molecules in hair cell stereocilia F-actin cores
Human deafness-associated variants alter the dynamics of key molecules in hair cell stereocilia F-actin cores
Takushi Miyoshi, Inna A. Belyantseva, Shin-ichiro Kitajiri, Hiroki Miyajima, Shin-ya Nishio, …, Bong Jik Kim, Byung Yoon Choi, Koichi Omori, Hari Shroff, Thomas B. Friedman
Human Genetics  ·  07 Jul 2021  ·  doi:10.1007/s00439-021-02304-0
Semi-automated single-molecule microscopy screening of fast-dissociating specific antibodies directly from hybridoma cultures
Semi-automated single-molecule microscopy screening of fast-dissociating specific antibodies directly from hybridoma cultures
Takushi Miyoshi, Qianli Zhang, Takafumi Miyake, Shin Watanabe, Hiroe Ohnishi, …, Benjamin J. Perrin, Hari Shroff, Thomas B. Friedman, Koichi Omori, Naoki Watanabe
Cell Reports  ·  01 Feb 2021  ·  doi:10.1016/j.celrep.2021.108708

2019

Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human<i>DIAPH1</i>-related cytoskeletopathy
Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of humanDIAPH1-related cytoskeletopathy
Bong Jik Kim, Takehiko Ueyama, Takushi Miyoshi, Seungmin Lee, Jin Hee Han, …, Sang Mee Hwang, Nayoung K D Kim, Woong-Yang Park, Shin-ichiro Kitajiri, Byung Yoon Choi
Journal of Medical Genetics  ·  31 Aug 2019  ·  doi:10.1136/jmedgenet-2019-106282
The phenotypic landscape of a Tbc1d24 mutant mouse includes convulsive seizures resembling human early infantile epileptic encephalopathy
The phenotypic landscape of a Tbc1d24 mutant mouse includes convulsive seizures resembling human early infantile epileptic encephalopathy
Risa Tona, Wenqian Chen, Yoko Nakano, Laura D Reyes, Ronald S Petralia, …, Carlo Pierpaoli, Botond Banfi, Lijin Dong, Inna A Belyantseva, Thomas B Friedman
Human Molecular Genetics  ·  02 Jan 2019  ·  doi:10.1093/hmg/ddy445

2016

Quantitative Analysis of Aquaporin Expression Levels during the Development and Maturation of the Inner Ear
Quantitative Analysis of Aquaporin Expression Levels during the Development and Maturation of the Inner Ear
Takushi Miyoshi, Taro Yamaguchi, Kiyokazu Ogita, Yasuko Tanaka, Ken-ichi Ishibashi, …, Taisuke Kobayashi, Takayuki Nakagawa, Juichi Ito, Koichi Omori, Norio Yamamoto
Journal of the Association for Research in Otolaryngology  ·  21 Dec 2016  ·  doi:10.1007/s10162-016-0607-3
Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss
Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss
Takehiko Ueyama, Yuzuru Ninoyu, Shin‐ya Nishio, Takushi Miyoshi, Hiroko Torii, …, Hirofumi Sakaguchi, Naoki Watanabe, Shin‐ichi Usami, Naoaki Saito, Shin‐ichiro Kitajiri
EMBO Molecular Medicine  ·  05 Oct 2016  ·  doi:10.15252/emmm.201606609

2015

Two Cases of Spindle Cell Carcinoma of the Head and Neck
Two Cases of Spindle Cell Carcinoma of the Head and Neck
Chiaki Suzuki, Satoshi Ohno, Shinji Takebayashi, Akiyoshi Yasumoto, Saki Yabuuchi, Takushi Miyoshi, Kumiko Gyo, Hiroki Ikeda, Ryo Asato, Makoto Miura
Practica Oto-Rhino-Laryngologica  ·  01 Jan 2015  ·  doi:10.5631/jibirin.108.375

2014

Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
Yosuke Tona, Kiyomi Hamaguchi, Masaaki Ishikawa, Takushi Miyoshi, Norio Yamamoto, Kohei Yamahara, Juichi Ito, Takayuki Nakagawa
BMC Neuroscience  ·  22 May 2014  ·  doi:10.1186/1471-2202-15-66

2013

Can filament treadmilling alone account for the F-actin turnover in lamellipodia?
Can filament treadmilling alone account for the F-actin turnover in lamellipodia?
Takushi Miyoshi, Naoki Watanabe
Cytoskeleton  ·  05 Mar 2013  ·  doi:10.1002/cm.21098
Hashimoto^|^rsquo;s Thyroiditis Affect the Outcome of Fine Needle Aspiration Biopsy
Hashimoto^|^rsquo;s Thyroiditis Affect the Outcome of Fine Needle Aspiration Biopsy
Shinji Takebayashi, Takushi Miyoshi, Chiaki Suzuki, Nao Hiwatashi, Hiroki Ikeda, Makoto Miura
Practica Oto-Rhino-Laryngologica  ·  01 Jan 2013  ·  doi:10.5631/jibirin.106.161

2012

A Case of Intraosseous Cavernous Hemangioma of the Maxillary Bone
A Case of Intraosseous Cavernous Hemangioma of the Maxillary Bone
Akiko Nishida, Hideyuki Fukushima, Takushi Miyoshi, Toshiki Maetani, Rie Kanai, Fumiko Kuboshima, Misaki Yamamoto, Takuya Tsuji, Shin-ichi Kanemaru
Practica Oto-Rhino-Laryngologica  ·  01 Jan 2012  ·  doi:10.5631/jibirin.105.431

2011

Early-Onset Postirradiation Sarcoma of the Tongue after Pseudotumor Phase
Early-Onset Postirradiation Sarcoma of the Tongue after Pseudotumor Phase
Takushi Miyoshi, Shinji Takebayashi, Chiaki Suzuki, Nao Hiwatashi, Hiroki Ikeda, Kazuo Ono, Makoto Miura
ORL  ·  01 Jan 2011  ·  doi:10.1159/000328977

2010

Breast Carcinoma Metastasis to the Temporal Bone
Breast Carcinoma Metastasis to the Temporal Bone
Koji Miyata, Hideyuki Fukushima, Toshiki Maetani, Akiko Nishida, Nobuya Fujiki, Nobumitsu Honda, Tsunemichi Adachi, Mika Tsujimura, Takushi Miyoshi
Practica Oto-Rhino-Laryngologica  ·  01 Jan 2010  ·  doi:10.5631/jibirin.103.209

2009

An Order of Magnitude Faster AIP1-Associated Actin Disruption than Nucleation by the Arp2/3 Complex in Lamellipodia
An Order of Magnitude Faster AIP1-Associated Actin Disruption than Nucleation by the Arp2/3 Complex in Lamellipodia
Takahiro Tsuji, Takushi Miyoshi, Chiharu Higashida, Shuh Narumiya, Naoki Watanabe
PLoS ONE  ·  17 Mar 2009  ·  doi:10.1371/journal.pone.0004921
Metastasis of Retroperitoneal Leiomyosarcoma to the Thyroid and Parotid Glands
Metastasis of Retroperitoneal Leiomyosarcoma to the Thyroid and Parotid Glands
Koji Miyata, Hideyuki Fukushima, Nobuya Fujiki, Nobumitsu Honda, Toshiki Maetani, Akiko Nishida, Yoshiharu Kitani, Tsunemichi Adachi, Mika Tsujimura, Takushi Miyoshi
Practica Oto-Rhino-Laryngologica  ·  01 Jan 2009  ·  doi:10.5631/jibirin.102.673

2006

Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing
Takushi Miyoshi, Takahiro Tsuji, Chiharu Higashida, Maud Hertzog, Akiko Fujita, Shuh Narumiya, Giorgio Scita, Naoki Watanabe
The Journal of Cell Biology  ·  18 Dec 2006  ·  doi:10.1083/jcb.200604176

2004

Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells
Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells
Chiharu Higashida, Takushi Miyoshi, Akiko Fujita, Fabian Oceguera-Yanez, James Monypenny, Yoshikazu Andou, Shuh Narumiya, Naoki Watanabe
Science  ·  26 Mar 2004  ·  doi:10.1126/science.1093923